Buy ARA-290 Research Peptide — High-Purity Non-Erythropoietic EPO Analog for Laboratory Use

Product Overview

ARA-290 (also known as Cibinetide) is a research-grade synthetic peptide derived from erythropoietin (EPO). It is supplied as a sterile lyophilized powder in sealed vials. Each package contains ten vials, with each vial holding 10mg of the research compound. This product is manufactured exclusively for scientific investigation and in vitro laboratory experimentation.

Key Specifications at a Glance:

• Quantity: 10mg per vial, 10 vials per pack

• Form: Lyophilized (freeze-dried) powder

• Purity: >98% verified by third-party testing

• Molecular Formula: C₅₁H₈₄N₁₆O₂₁

• Molecular Mass: 1257.3

• CAS Number: 1208243-50-8

• Sequence: Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH

• Synonyms: Cibinetide, PHBSP, Pyroglutamate Helix B Surface Peptide

• Research Use Only: Not for human or animal consumption

Understanding ARA-290: The Research Context

ARA-290 is an 11-amino acid synthetic peptide derived from the helix B domain of erythropoietin (EPO). Unlike full-length EPO, which stimulates red blood cell production through the classical EPO receptor, ARA-290 was specifically engineered to isolate the tissue-protective and anti-inflammatory activities of EPO without the erythropoietic (red blood cell-stimulating) effects.

Key Research Interests:

• Innate repair receptor (IRR) activation and signaling

• Neuropathic pain mechanisms and nerve regeneration

• Anti-inflammatory pathway modulation

• Tissue protection and repair in metabolic conditions

• In vitro cell culture investigations

Researchers utilize ARA-290 in controlled laboratory settings to study the selective activation of tissue-protective pathways. The peptide is of particular interest to investigators focused on neuropathic pain, small fiber neuropathy, inflammatory conditions, and tissue repair mechanisms. Buy ARA-290

The Significance of Non-Erythropoietic EPO Analogs:
Erythropoietin has long been recognized for its tissue-protective properties beyond red blood cell production. However, the erythropoietic activity of EPO limits its research applications due to effects on hematocrit. ARA-290 was designed to target the innate repair receptor (IRR) rather than the classical EPO receptor, aiming to modulate the immune microenvironment toward resolution of inflammation and tissue protection without affecting red blood cell production. Buy ARA-290

Third-Party Testing and Quality Assurance

Every batch of ARA-290 undergoes rigorous independent analytical testing to verify identity, purity, and consistency. This third-party testing ensures that researchers receive a product that meets strict quality specifications before it is approved for release. Buy ARA-290

The testing process includes:

• Identity verification through mass spectrometry

• Purity analysis using high-performance liquid chromatography (HPLC)

• Batch-to-batch consistency checks

• Endotoxin testing for bioburden control

• Residual solvent analysis to confirm complete lyophilization

With a verified purity exceeding 98%, ARA-290 meets the high standards required for serious laboratory research applications. Each vial contains only the lyophilized research compound with no unnecessary additives, fillers, or excipients.

Chemical and Physical Properties

Molecular Characteristics

ARA-290 is an 11-amino acid linear peptide with a pyroglutamate (Pyr) modification at the N-terminus.

Detailed Molecular Information:

• Molecular Formula: C₅₁H₈₄N₁₆O₂₁

• Molecular Mass: 1257.3 daltons

• CAS Number: 1208243-50-8

• PubChem CID: 91810664

• Sequence: Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH

Full Sequence Breakdown with Properties:

Structural Features:

• Linear 11-amino acid peptide

• Pyroglutamate (Pyr) modification at N-terminus for stability

• Contains both positively and negatively charged residues

• Hydrophobic leucine residues at positions 4 and 8

• No disulfide bonds or cyclic structures

• Free C-terminus (-OH)

The pyroglutamate modification at the N-terminus is a notable structural feature. This cyclized form of glutamate protects the peptide from degradation by aminopeptidases, enhancing stability compared to unmodified peptides. Buy ARA-290

Physical Form and Storage

The product is supplied as a lyophilized (freeze-dried) powder within a sterile, sealed vial. The powder typically appears as a white to off-white substance.

Recommended Storage Conditions:

• Store lyophilized powder at -20°C (-4°F) or below for long-term preservation

• Protect from light exposure

• Keep desiccated to prevent moisture absorption

• Allow vial to reach room temperature before opening to avoid condensation

• Avoid repeated freeze-thaw cycles once reconstituted

Stability Considerations:
ARA-290 is generally stable when stored properly in lyophilized form. However, like all peptides, it should be handled with standard precautions. The pyroglutamate modification provides enhanced resistance to N-terminal degradation compared to unmodified peptides.

Once reconstituted with an appropriate sterile solvent, the solution should be used promptly according to laboratory protocols.

Intended Use and Regulatory Status

Research Use Only

ARA-290 is classified as a research chemical and is intended exclusively for laboratory and in vitro experimentation. This designation means the product is sold strictly for:

• In vitro testing — experiments conducted in controlled laboratory environments

• Cell culture studies — investigating IRR activation and signaling pathways

• Neuropathic pain research — studying nerve regeneration and pain mechanisms

• Anti-inflammatory research — investigating cytokine and inflammatory pathway modulation

• Tissue repair studies — examining protection and repair in metabolic conditions

• Analytical research — chemical analysis and characterization studies

• Scientific investigation — basic research into EPO analog structure and function

Important Regulatory Notice

This product is not a drug, food, cosmetic, or medical device. Bodily introduction of any kind into humans or animals is strictly forbidden by law. The product should only be handled by licensed, qualified professionals working in appropriate laboratory facilities. Buy ARA-290

ARA-290 is not an approved drug product for general medical use in most jurisdictions. It is sold as a research peptide, meaning the buyer assumes responsibility for scrutinizing quality, documentation, and vendor credibility.

The supplier is a chemical supplier, not a compounding pharmacy or outsourcing facility under Sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act. All product information provided is for educational and research purposes only and does not constitute medical advice or clinical recommendations. Buy ARA-290

Handling and Safety Guidelines

Professional Handling Required

ARA-290 should only be handled by trained laboratory personnel wearing appropriate personal protective equipment (PPE), including:

• Laboratory coat

• Nitrile gloves

• Safety goggles or face shield

• Appropriate respiratory protection if aerosolization is possible

Reconstitution Protocol

For laboratory use, the lyophilized powder should be reconstituted with a sterile, compatible solvent. Standard practice includes:

1. Allow the sealed vial to reach room temperature — approximately 15-30 minutes

2. Clean the rubber stopper with an alcohol swab

3. Add the calculated volume of solvent to achieve desired concentration

4. Gently swirl or roll the vial between palms — do not shake vigorously to avoid foaming

5. Allow complete dissolution before use — this typically takes 2-5 minutes

Reconstitution Example for ARA-290 10MG:
For researchers needing a 5mg/mL working solution, add 2mL of sterile solvent to the 10mg vial. For a 10mg/mL solution, add 1mL of solvent. For a 2mg/mL solution, add 5mL of solvent. For a 1mg/mL solution, add 10mL of solvent. Always verify calculations before proceeding with experiments. Buy ARA-290

Solvent Considerations:
ARA-290 is water-soluble. Researchers should determine the appropriate solvent based on their specific experimental protocol. Common options include sterile water for injection, bacteriostatic water, or buffered solutions such as phosphate-buffered saline (PBS) at neutral pH. Buy ARA-290

Quality Documentation

For serious research use, request the following documentation from your supplier:

• Certificate of Analysis (CoA): Batch-specific, not a generic document

• HPLC chromatogram: For purity verification

• Mass spectrometry data: For identity confirmation

• Endotoxin testing results: For bioburden assessment

Disposal Considerations

Dispose of ARA-290 and any contaminated materials in accordance with federal, state, and local regulations for chemical waste disposal. Do not dispose of in regular trash or down drains unless permitted by local guidelines. Buy ARA-290

Research Applications

ARA-290 is used in various laboratory research contexts, primarily focused on neuropathic pain, inflammation, and tissue protection. Typical applications include:

Innate Repair Receptor (IRR) Studies:
The primary research interest in ARA-290 revolves around its selective activation of the innate repair receptor. Researchers use ARA-290 to study:

• IRR activation mechanisms and signaling pathways

• Receptor binding specificity versus classical EPO receptor

• Downstream cytoprotective signaling cascades

Neuropathic Pain and Nerve Regeneration Research:
ARA-290 has been investigated for its effects on nerve function and pain signaling. Research applications include:

• Small fiber neuropathy mechanisms

• Peripheral nerve regeneration pathways

• Neuropathic pain signaling and modulation

• Schwann cell and neuronal survival studies

Anti-Inflammatory Pathway Studies:
ARA-290 has been studied for its ability to modulate inflammatory responses. Researchers use ARA-290 to investigate:

• Pro-inflammatory cytokine regulation

• Macrophage polarization and function

• Resolution of inflammation mechanisms

• Inflammatory signaling pathway modulation

Tissue Protection and Repair Research:
ARA-290 is used to study tissue-protective mechanisms in various research models:

• Ischemia-reperfusion injury protection

• Metabolic stress responses

• Wound healing and tissue repair pathways

• Cellular survival under oxidative stress

Metabolic Research:
ARA-290 has been studied in metabolic research contexts, including:

• Diabetic neuropathy models

• Metabolic syndrome-related inflammation

• Cholesterol and metabolic marker studies

Cell Culture Investigations:
Researchers use ARA-290 in controlled cell culture systems to study:

• Neuronal cell survival and differentiation

• Schwann cell proliferation and migration

• Macrophage inflammatory responses

• Endothelial cell protection under stress conditions

Experimental Autoimmune Models:
ARA-290 has been studied in autoimmune research models, including experimental autoimmune encephalomyelitis (EAE). Research applications include:

• Neuroinflammatory pathway modulation

• Immune cell infiltration studies

• Demyelination and remyelination mechanisms

Researchers should design their experimental protocols based on peer-reviewed literature and established laboratory practices specific to EPO-derived peptides.

What Makes This Product Different

Selective Non-Erythropoietic EPO Analog

Unlike full-length erythropoietin or other EPO derivatives, ARA-290 was specifically engineered to activate the innate repair receptor (IRR) without stimulating red blood cell production. This selectivity allows researchers to study tissue-protective pathways without the confounding effects of erythropoiesis. Buy ARA-290

Pyroglutamate Modification for Stability

The N-terminal pyroglutamate (Pyr) modification provides enhanced resistance to enzymatic degradation compared to unmodified peptides. This structural feature makes ARA-290 more stable in laboratory settings. Buy ARA-290

Well-Characterized Research History

ARA-290 has been the subject of numerous preclinical and exploratory human studies, with published research in areas including neuropathic pain, small fiber neuropathy, inflammatory conditions, and tissue injury. Buy ARA-290

Rigorous Quality Control

Unlike research chemicals sold without verification, quality-grade ARA-290 comes with documented third-party testing for every batch. This commitment to quality assurance gives researchers confidence in the consistency and reliability of their experimental results.

Complete Documentation

Quality suppliers provide full chemical specifications, including molecular formula, molecular mass, CAS number, and amino acid sequence. Batch-specific Certificates of Analysis (CoA) should include HPLC purity, mass spectrometry identity confirmation, and endotoxin testing results. Buy ARA-290

Appropriate Packaging for Research Use

The sterile, sealed vial packaging protects the lyophilized powder from environmental contaminants. The 10mg concentration is optimized for laboratory research applications requiring precise handling. Buy ARA-290

Batch Traceability

Quality-sourced ARA-290 includes batch identification numbers that allow researchers to trace their material back to original manufacturing and testing records. This traceability is essential for reproducible research and quality documentation.

Frequently Asked Questions for Researchers

What is the purity level of ARA-290?

Quality-sourced ARA-290 is tested to verify purity exceeding 98% by HPLC. Individual certificates of analysis are available upon request.

What is the significance of the CAS number 1208243-50-8?

The CAS number is a unique identifier for ARA-290 (Cibinetide), allowing researchers to verify they are working with the correct chemical compound when ordering or referencing the peptide in publications.

What is the amino acid sequence of ARA-290?

The sequence is Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH, where Pyr represents pyroglutamate.

How does ARA-290 differ from erythropoietin (EPO)?

ARA-290 is an 11-amino acid peptide derived from EPO that selectively activates the innate repair receptor (IRR) without the erythropoietic (red blood cell-stimulating) effects of full-length EPO.

What is the pyroglutamate (Pyr) modification?

Pyroglutamate is a cyclized form of glutamate at the N-terminus that protects the peptide from degradation by aminopeptidases, enhancing stability.

How should the lyophilized powder be stored?

Store at -20°C or below, protected from light and moisture. Avoid repeated freeze-thaw cycles once reconstituted.

What solvent should be used for reconstitution?

ARA-290 is water-soluble. Researchers should determine the appropriate solvent based on their specific experimental protocol. Common options include sterile water for injection, bacteriostatic water, or buffered solutions such as PBS at neutral pH. Buy ARA-290

Is this product sterile?

The lyophilized powder is manufactured under aseptic conditions, but researchers should follow standard laboratory practices for handling research chemicals. For cell culture applications, additional filtration using a 0.22-micron filter may be appropriate. Quality documentation should include endotoxin testing results.

What research applications is ARA-290 used for?

ARA-290 is studied in neuropathic pain research, small fiber neuropathy models, anti-inflammatory pathway investigations, tissue protection studies, and metabolic research in laboratory cell culture and preclinical models.

Can ARA-290 be used in combination with other research peptides?

Researchers should determine compatibility based on their specific experimental design. Standard laboratory practice includes testing interactions in control experiments before full-scale implementation.

Final Notes for Laboratory Researchers

ARA-290 represents a high-purity research tool for qualified professionals conducting legitimate scientific investigations into innate repair receptor signaling, neuropathic pain mechanisms, anti-inflammatory pathways, tissue protection, and related fields. With documented third-party testing, complete chemical specifications, and appropriate packaging for laboratory use, this product meets the standards expected by serious researchers.

The 10mg vial size is optimized for smaller-scale experiments, preliminary studies, and protocols requiring precise handling. For larger-scale research, multiple vials can be used to achieve the desired quantity. When sourcing ARA-290, prioritize suppliers that provide batch-specific Certificates of Analysis, including HPLC purity data, mass spectrometry identity confirmation, and endotoxin testing results.

For research use only. Not for human or animal consumption. Handle only in appropriate laboratory facilities with proper safety equipment and training.