SELANK Research Peptide — Synthetic ACTH(4-10) Analog for Laboratory Use

Product Overview

SELANK is a research-grade synthetic heptapeptide derived from the N-terminal fragment (4-10) of adrenocorticotropic hormone (ACTH). It is supplied as a sterile lyophilized powder in sealed vials. Each package contains ten vials, with each vial holding 10mg of the research compound. This product is manufactured exclusively for scientific investigation and in vitro laboratory experimentation.

Key Specifications at a Glance:

• Quantity: 10mg per vial, 10 vials per pack

• Form: Lyophilized (freeze-dried) powder

• Purity: >98% verified by third-party testing

• Molecular Formula: C₃₆H₅₃N₉O₁₀

• Molecular Mass: 751.83

• CAS Number: 220501-39-7

• Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)

• Research Use Only: Not for human or animal consumption

Understanding SELANK: The Research Context

SELANK is a synthetic heptapeptide that belongs to the same family of ACTH(4-10) analogs as SEMAX. It is structurally related to SEMAX but lacks the sulfur-containing methionine sulfoxide modification found in SEMAX, giving it a distinct molecular mass (751.83 vs. 813.92 for SEMAX).

Key Research Interests:

• Anxiolytic (anxiety-reducing) properties

• Neuroprotective mechanisms

• Cognitive function modulation

• Stress response research

• In vitro cell culture investigations

Researchers utilize SELANK in controlled laboratory settings to better understand the molecular mechanisms underlying its anxiolytic and neuroprotective properties. The peptide is of particular interest to investigators focused on stress biology, anxiety disorders, and neuropharmacology.

The Significance of the ACTH(4-10) Backbone:
The ACTH(4-10) fragment (Met-Glu-His-Phe-Arg-Trp-Gly) is known to influence learning and memory processes. SELANK is a synthetic analog of this fragment, designed to be more stable and selective in its biological activity. Unlike SEMAX, which contains a methionine sulfoxide residue, SELANK maintains the native methionine structure while incorporating stabilizing modifications.

SELANK vs. SEMAX: A Research Comparison

Researchers often ask about the differences between SELANK and SEMAX, as both are derived from ACTH(4-10) but serve different research purposes.

Choosing Between SELANK and SEMAX:
Researchers focused on anxiety, stress responses, and related neuropharmacological mechanisms may find SELANK more appropriate for their studies. Those investigating cognitive enhancement, BDNF modulation, and broader nootropic effects may prefer SEMAX. Both peptides offer unique properties that make them valuable tools in neuroscience research.

Third-Party Testing and Quality Assurance

Every batch of SELANK undergoes rigorous independent analytical testing to verify identity, purity, and consistency. This third-party testing ensures that researchers receive a product that meets strict quality specifications before it is approved for release.

The testing process includes:

• Identity verification through mass spectrometry

• Purity analysis using high-performance liquid chromatography (HPLC)

• Batch-to-batch consistency checks

• Residual solvent analysis to confirm complete lyophilization

With a verified purity exceeding 98%, SELANK meets the high standards required for serious laboratory research applications. Each vial contains only the lyophilized research compound with no unnecessary additives, fillers, or excipients.

Chemical and Physical Properties

Molecular Characteristics

SELANK is a synthetic heptapeptide with the amino acid sequence Methionine-Glutamic Acid-Histidine-Phenylalanine-Proline-Glycine-Proline (MEHFPGP).

Detailed Molecular Information:

• Molecular Formula: C₃₆H₅₃N₉O₁₀

• Molecular Mass: 751.83 daltons

• CAS Number: 220501-39-7

• Isoelectric Point (pI): 5.38

Structural Features:

• Contains methionine in its native (non-oxidized) form

• No sulfur content (unlike SEMAX which contains methionine sulfoxide)

• Stabilized C-terminus with Pro-Gly-Pro modification

The absence of sulfur in the molecular formula distinguishes SELANK from SEMAX and other sulfur-containing peptides. This structural difference contributes to SELANK’s unique stability profile and biological properties.

Physical Form and Storage

The product is supplied as a lyophilized (freeze-dried) powder within a sterile, sealed vial. Lyophilization preserves the chemical integrity of the peptide by removing water content while maintaining the compound’s native structure. This form allows for extended stability when stored properly.

Recommended Storage Conditions:

• Store lyophilized powder at -20°C (-4°F) or below for long-term preservation

• Protect from light exposure

• Keep desiccated to prevent moisture absorption

• Allow vial to reach room temperature before opening to avoid condensation

• Avoid repeated freeze-thaw cycles once reconstituted

Stability Considerations:
SELANK is generally stable when stored properly in lyophilized form. Because it lacks the sulfur-containing methionine sulfoxide residue found in SEMAX, SELANK may have different oxidation characteristics. However, standard peptide handling precautions should still be observed.

Once reconstituted with an appropriate sterile solvent, the solution should be used promptly according to laboratory protocols.

Intended Use and Regulatory Status

Research Use Only

SELANK is classified as a research chemical and is intended exclusively for laboratory and in vitro experimentation. This designation means the product is sold strictly for:

• In vitro testing — experiments conducted in controlled laboratory environments

• Cell culture studies — investigating peptide interactions with cellular systems

• Neuroscience research — studying anxiolytic and neuroprotective mechanisms

• Stress biology research — investigating stress response pathways

• Analytical research — chemical analysis and characterization studies

• Scientific investigation — basic research into peptide structure and function

Important Regulatory Notice

This product is not a drug, food, cosmetic, or medical device. Bodily introduction of any kind into humans or animals is strictly forbidden by law. The product should only be handled by licensed, qualified professionals working in appropriate laboratory facilities.

The supplier is a chemical supplier, not a compounding pharmacy or outsourcing facility under Sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act. All product information provided is for educational purposes only and does not constitute medical advice or clinical recommendations.

Handling and Safety Guidelines

Professional Handling Required

SELANK should only be handled by trained laboratory personnel wearing appropriate personal protective equipment (PPE), including:

• Laboratory coat

• Nitrile gloves

• Safety goggles or face shield

• Appropriate respiratory protection if aerosolization is possible

Reconstitution Protocol

For laboratory use, the lyophilized powder should be reconstituted with a sterile, compatible solvent. Standard practice includes:

1. Allow the sealed vial to reach room temperature — approximately 15-30 minutes

2. Clean the rubber stopper with an alcohol swab

3. Add the calculated volume of solvent to achieve desired concentration

4. Gently swirl or roll the vial between palms — do not shake vigorously to avoid foaming and denaturation

5. Allow complete dissolution before use — this typically takes 2-5 minutes

Reconstitution Example for SELANK:
For researchers needing a 5mg/mL working solution, add 2mL of sterile solvent to the 10mg vial. For a 10mg/mL solution, add 1mL of solvent. For a 2mg/mL solution, add 5mL of solvent. For a 1mg/mL solution, add 10mL of solvent. Always verify calculations before proceeding with experiments.

Solvent Considerations:
Researchers should determine the appropriate solvent based on their specific experimental protocol. Common options include sterile water for injection, bacteriostatic water, or buffered solutions. The choice of solvent may affect peptide stability and should be validated for each experimental application.

Disposal Considerations

Dispose of SELANK and any contaminated materials in accordance with federal, state, and local regulations for chemical waste disposal. Do not dispose of in regular trash or down drains unless permitted by local guidelines.

Research Applications

SELANK is used in various laboratory research contexts, primarily focused on neuroscience, stress biology, and neuropharmacology. Typical applications include:

Anxiolytic Mechanism Studies:
The primary research interest in SELANK revolves around its anxiolytic (anxiety-reducing) properties. Researchers use SELANK to investigate:

• Molecular pathways involved in anxiety modulation

• Receptor binding sites and mechanisms of action

• Neurotransmitter systems involved in stress responses

• Gene expression changes associated with anxiolytic effects

Stress Response Research:
SELANK has been the subject of research into its effects on stress-related pathways. Studies focus on:

• Hypothalamic-pituitary-adrenal (HPA) axis modulation

• Corticosterone and cortisol regulation

• Stress-induced behavioral changes

• Neuroendocrine response mechanisms

Neuroprotection Investigations:
Researchers study SELANK for its potential neuroprotective properties, including:

• Protection against stress-induced neuronal damage

• Maintenance of neuronal integrity under challenging conditions

• Support of neuronal survival pathways

Cognitive Function Studies:
While SELANK is primarily associated with anxiolytic effects, researchers also investigate its influence on:

• Learning and memory processes

• Attention and focus mechanisms

• Cognitive performance under stress conditions

Receptor Binding and Signaling Research:
Investigators use SELANK to study:

• Specific binding sites in neural tissue

• Second messenger system activation

• Downstream signaling pathways

• Calcium-dependent binding mechanisms

Structure-Activity Relationship (SAR) Analysis:
The synthetic nature of SELANK allows researchers to study how specific structural features contribute to its biological activity, particularly in comparison to related peptides like SEMAX.

Researchers should design their experimental protocols based on peer-reviewed literature and established laboratory practices specific to ACTH analog peptides.

What Makes This Product Different

Unique Anxiolytic-Focused ACTH(4-10) Analog

Unlike many research peptides that focus primarily on cognitive enhancement, SELANK is specifically associated with anxiolytic (anxiety-reducing) properties. This unique focus makes SELANK a valuable research tool for investigators studying stress biology, anxiety mechanisms, and related neuropharmacological pathways.

Distinct Molecular Structure

SELANK has a molecular mass of 751.83, distinguishing it from SEMAX (813.92) and other ACTH(4-10) analogs. This structural difference contributes to SELANK’s unique biological properties and research applications.

Rigorous Quality Control

Unlike research chemicals sold without verification, SELANK comes with documented third-party testing for every batch. This commitment to quality assurance gives researchers confidence in the consistency and reliability of their experimental results.

Complete Documentation

Each product listing includes full chemical specifications, including molecular formula, molecular mass, CAS number, and amino acid sequence. This transparency allows researchers to verify the exact compound they are working with.

Appropriate Packaging for Research Use

The sterile, sealed vial packaging protects the lyophilized powder from environmental contaminants. The 10mg concentration is particularly useful for experiments requiring precise, smaller-scale handling.

Batch Traceability

Each package of SELANK includes batch identification numbers that allow researchers to trace their material back to original manufacturing and testing records. This traceability is essential for reproducible research and quality documentation.

Frequently Asked Questions for Researchers

What is the purity level of SELANK?

Each batch is tested to verify purity exceeding 98%. Individual certificates of analysis are available upon request.

How should the lyophilized powder be stored?

Store at -20°C or below, protected from light and moisture. Avoid repeated freeze-thaw cycles once reconstituted.

What solvent should be used for reconstitution?

Researchers should determine the appropriate solvent based on their specific experimental protocol. Common options include sterile water for injection, bacteriostatic water, or buffered solutions such as phosphate-buffered saline (PBS).

Is this product sterile?

The lyophilized powder is manufactured under aseptic conditions, but researchers should follow standard laboratory practices for handling research chemicals. For cell culture applications, additional filtration using a 0.22-micron filter may be appropriate.

What is the significance of the CAS number 220501-39-7?

The CAS number is a unique identifier for SELANK, allowing researchers to verify they are working with the correct chemical compound when ordering or referencing the peptide in publications.

What is the amino acid sequence of SELANK?

The sequence is Methionine-Glutamic Acid-Histidine-Phenylalanine-Proline-Glycine-Proline, abbreviated as MEHFPGP — the same sequence as SEMAX but with a different oxidation state of methionine.

How does SELANK differ from SEMAX?

SELANK and SEMAX share the same amino acid sequence (MEHFPGP) but differ in the oxidation state of the methionine residue. SEMAX contains methionine sulfoxide, giving it a higher molecular mass (813.92 vs. 751.83) and distinct properties. SELANK contains methionine in its native, non-oxidized form.

Can SELANK be used in combination with other research peptides?

Researchers should determine compatibility based on their specific experimental design. Standard laboratory practice includes testing interactions in control experiments before full-scale implementation.

Final Notes for Laboratory Researchers

SELANK represents a high-purity research tool for qualified professionals conducting legitimate scientific investigations into anxiolytic mechanisms, stress biology, neuroprotection, and related neuropharmacological fields. With documented third-party testing, complete chemical specifications, and appropriate packaging for laboratory use, this product meets the standards expected by serious researchers.

The 10mg vial size is optimized for smaller-scale experiments, preliminary studies, and protocols requiring precise handling. For larger-scale research, multiple vials can be used to achieve the desired quantity.

For research use only. Not for human or animal consumption. Handle only in appropriate laboratory facilities with proper safety equipment and training.