TB-500 Research Peptide — High-Purity Synthetic Thymosin Beta-4 Derivative for Laboratory Use
Product Overview
TB-500 is a research-grade synthetic peptide derived from the naturally occurring protein thymosin beta-4. It is supplied as a sterile lyophilized powder in sealed vials. Each package contains ten vials, with each vial holding 10mg of the research compound. This product is manufactured exclusively for scientific investigation and in vitro laboratory experimentation.
Key Specifications at a Glance:
Quantity: 10mg per vial, 10 vials per pack
Form: Lyophilized (freeze-dried) powder
Purity: >99% verified by third-party testing
Molecular Mass: 4963.5
CAS Number: 885340-08-9
Source: Synthetic peptide derived from thymosin beta-4
Research Use Only: Not for human or animal consumption
Understanding TB-500: The Research Context
TB-500 represents a synthetic version of a segment of the naturally occurring protein thymosin beta-4. Thymosin beta-4 is found in virtually all human and animal cells and plays multiple roles in cellular biology. The TB-500 peptide corresponds to the active region of this larger protein, allowing researchers to study its properties in isolation.
Key Research Interests:
Cellular migration and movement studies
Cytoskeletal dynamics and actin binding research
In vitro cell culture investigations
Receptor interaction and signaling pathway analysis
Researchers utilize TB-500 in controlled laboratory settings to better understand the fundamental biological processes involving thymosin beta-4 and its synthetic derivatives.
Third-Party Testing and Quality Assurance
Every batch of TB-500 undergoes rigorous independent analytical testing to verify identity, purity, and consistency. This third-party testing ensures that researchers receive a product that meets strict quality specifications before it is approved for release.
The testing process includes:
Identity verification through mass spectrometry
Purity analysis using high-performance liquid chromatography (HPLC)
Batch-to-batch consistency checks
Residual solvent analysis to confirm complete lyophilization
With a verified purity exceeding 99%, TB-500 meets the high standards required for serious laboratory research applications. Each vial contains only the lyophilized research compound with no unnecessary additives, fillers, or excipients.
Chemical and Physical Properties
Molecular Characteristics
TB-500 is a synthetic peptide with a specific amino acid sequence corresponding to the active region of thymosin beta-4. Its molecular mass is 4963.5 daltons. The compound is registered under CAS number 885340-08-9.
The peptide is known for its ability to bind to actin, a fundamental protein involved in cell structure and movement. This actin-binding property is a primary focus of TB-500 research in laboratory settings.
Physical Form and Storage
The product is supplied as a lyophilized (freeze-dried) powder within a sterile, sealed vial. Lyophilization preserves the chemical integrity of the peptide by removing water content while maintaining the compound’s structure.
Recommended Storage Conditions:
Store lyophilized powder at -20°C (-4°F) or below for long-term preservation
Protect from light exposure
Keep desiccated to prevent moisture absorption
Allow vial to reach room temperature before opening to avoid condensation
Avoid repeated freeze-thaw cycles once reconstituted
Stability Considerations:
TB-500 is generally stable when stored properly in lyophilized form. However, like all peptides, it is susceptible to degradation over time. Researchers should note the manufacturing date and plan experiments accordingly to ensure they are working with material that has been stored under appropriate conditions.
Once reconstituted with an appropriate sterile solvent, the solution should be used promptly according to laboratory protocols.
Intended Use and Regulatory Status
Research Use Only
TB-500 is classified as a research chemical and is intended exclusively for laboratory and in vitro experimentation. This designation means the product is sold strictly for:
In vitro testing — experiments conducted in controlled laboratory environments
Cell culture studies — investigating peptide interactions with cellular systems
Analytical research — chemical analysis and characterization studies
Actin binding assays — studying cytoskeletal interactions
Scientific investigation — basic research into peptide structure and function
Important Regulatory Notice
This product is not a drug, food, cosmetic, or medical device. Bodily introduction of any kind into humans or animals is strictly forbidden by law. The product should only be handled by licensed, qualified professionals working in appropriate laboratory facilities.
The supplier is a chemical supplier, not a compounding pharmacy or outsourcing facility under Sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act. All product information provided is for educational purposes only and does not constitute medical advice or clinical recommendations.
Handling and Safety Guidelines
Professional Handling Required
TB-500 should only be handled by trained laboratory personnel wearing appropriate personal protective equipment (PPE), including:
Reconstitution Protocol
For laboratory use, the lyophilized powder should be reconstituted with a sterile, compatible solvent. Standard practice includes:
Allow the sealed vial to reach room temperature — approximately 15-30 minutes
Clean the rubber stopper with an alcohol swab
Add the calculated volume of solvent to achieve desired concentration
Gently swirl or roll the vial between palms — do not shake vigorously to avoid foaming
Allow complete dissolution before use — this typically takes 2-5 minutes
Reconstitution Example for TB-500:
For researchers needing a 5mg/mL working solution, add 2mL of sterile solvent to the 10mg vial. For a 10mg/mL solution, add 1mL of solvent. For a 2mg/mL solution, add 5mL of solvent. For a 1mg/mL solution, add 10mL of solvent. Always verify calculations before proceeding with experiments.
Disposal Considerations
Dispose of TB-500 and any contaminated materials in accordance with federal, state, and local regulations for chemical waste disposal. Do not dispose of in regular trash or down drains unless permitted by local guidelines.
Research Applications
TB-500 is used in various laboratory research contexts. Typical applications include:
Actin Binding Studies:
The primary research interest in TB-500 revolves around its ability to bind actin, a globular protein that forms microfilaments. Actin is a fundamental component of the cytoskeleton, and studying actin-binding peptides helps researchers understand cellular structure and movement.
Cell Migration Research:
Because actin dynamics are central to cell movement, TB-500 is used in in vitro studies examining how cells migrate. These studies contribute to basic biological knowledge.
Cytoskeleton Investigations:
The cytoskeleton provides structural support and enables cellular movement. TB-500 serves as a research tool for investigating cytoskeletal organization and dynamics.
Receptor Binding Studies:
Researchers may use TB-500 to investigate potential receptor interactions and downstream signaling pathways in controlled cell culture systems.
Structure-Activity Relationship (SAR) Analysis:
The synthetic nature of TB-500 allows researchers to study how specific structural features contribute to its biological activity.
Researchers should design their experimental protocols based on peer-reviewed literature and established laboratory practices specific to thymosin beta-4 derived peptides.
What Makes This Product Different
Rigorous Quality Control
Unlike research chemicals sold without verification, TB-500 comes with documented third-party testing for every batch. This commitment to quality assurance gives researchers confidence in the consistency and reliability of their experimental results.
Complete Documentation
Each product listing includes full chemical specifications, including molecular mass and CAS number. This transparency allows researchers to verify the exact compound they are working with.
Appropriate Packaging for Research Use
The sterile, sealed vial packaging protects the lyophilized powder from environmental contaminants. The 10mg concentration is particularly useful for experiments requiring precise, smaller-scale handling.
Batch Traceability
Each package of TB-500 includes batch identification numbers that allow researchers to trace their material back to original manufacturing and testing records. This traceability is essential for reproducible research and quality documentation.
Frequently Asked Questions for Researchers
What is the purity level of TB-500?
Each batch is tested to verify purity exceeding 99%. Individual certificates of analysis are available upon request.
How should the lyophilized powder be stored?
Store at -20°C or below, protected from light and moisture. Avoid repeated freeze-thaw cycles once reconstituted.
What solvent should be used for reconstitution?
Researchers should determine the appropriate solvent based on their specific experimental protocol. Common options include sterile water for injection, bacteriostatic water, or buffered solutions such as phosphate-buffered saline (PBS).
Is this product sterile?
The lyophilized powder is manufactured under aseptic conditions, but researchers should follow standard laboratory practices for handling research chemicals. For cell culture applications, additional filtration using a 0.22-micron filter may be appropriate.
How does TB-500 differ from thymosin beta-4?
TB-500 is a synthetic peptide representing a specific segment of the larger thymosin beta-4 protein. Researchers use TB-500 to study the active region in isolation.
What is the significance of the CAS number 885340-08-9?
The CAS number is a unique identifier for TB-500, allowing researchers to verify they are working with the correct chemical compound when ordering or referencing the peptide in publications.
Can TB-500 be used in combination with other research peptides?
Researchers should determine compatibility based on their specific experimental design. Standard laboratory practice includes testing interactions in control experiments before full-scale implementation.
Final Notes for Laboratory Researchers
TB-500 represents a high-purity research tool for qualified professionals conducting legitimate scientific investigations into actin binding, cytoskeletal dynamics, and cellular biology. With documented third-party testing, complete chemical specifications, and appropriate packaging for laboratory use, this product meets the standards expected by serious researchers.
The 10mg vial size is optimized for smaller-scale experiments, preliminary studies, and protocols requiring precise handling. For larger-scale research, multiple vials can be used to achieve the desired quantity.
For research use only. Not for human or animal consumption. Handle only in appropriate laboratory facilities with proper safety equipment and training.
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