Ipamorelin Research Peptide — High-Purity Selective Growth Hormone Secretagogue for Laboratory Use

Product Overview

Ipamorelin is a research-grade synthetic pentapeptide belonging to the growth hormone secretagogue (GHS) family. It is supplied as a sterile lyophilized powder in sealed vials. Each package contains ten vials, with each vial holding 5mg of the research compound. This product is manufactured exclusively for scientific investigation and in vitro laboratory experimentation.

Key Specifications at a Glance:

• Quantity: 5mg per vial, 10 vials per pack

• Form: Lyophilized (freeze-dried) powder

• Purity: >99% verified by third-party testing

• Molecular Formula: C₃₈H₄₉N₉O₅

• Molecular Mass: 711.85

• CAS Number: 170851-70-4

• Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH₂

• Synonyms: NNC 26-0703, Aib-His-D-2-Nal-D-Phe-Lys-NH₂

• Research Use Only: Not for human or animal consumption

Understanding Ipamorelin: The Research Context

Ipamorelin is a synthetic pentapeptide that functions as a selective agonist at the growth hormone secretagogue receptor (GHSR). It was developed as a third-generation growth hormone secretagogue with a distinct pharmacological profile that distinguishes it from earlier compounds like GHRP-6 and GHRP-2.

Key Research Interests:

• Growth hormone secretagogue receptor (GHSR) activation

• Pituitary somatotroph function and signaling

• Growth hormone pulse amplitude modulation

• In vitro cell culture investigations

• Neuroendocrine regulation studies

Researchers utilize Ipamorelin in controlled laboratory settings to study the growth hormone axis and its regulation. The peptide is of particular interest to investigators focused on endocrinology, neuroendocrinology, and the fundamental mechanisms of pituitary hormone secretion.

The Significance of Selectivity in Growth Hormone Secretagogues:
Early growth hormone secretagogues, while effective at stimulating growth hormone release, were associated with increases in other hormones such as cortisol and prolactin. Ipamorelin was developed to be more selective, with research indicating that it stimulates growth hormone release with minimal effects on other pituitary hormones. This selectivity makes Ipamorelin a valuable research tool for investigators studying isolated growth hormone axis activation without the confounding effects of broader hormonal changes.

Ipamorelin in the Growth Hormone Secretagogue Family

Ipamorelin belongs to the growth hormone secretagogue (GHS) family of peptides, which includes several compounds with distinct properties.

Comparison of Common GHS Research Peptides:

Research Significance of Ipamorelin’s Selectivity:
The selectivity profile of Ipamorelin allows researchers to:

• Study growth hormone release with minimal interference from other hormonal pathways

• Isolate GHSR-mediated effects from broader pituitary activation

• Investigate growth hormone axis regulation without confounding cortisol or prolactin changes

Third-Party Testing and Quality Assurance

Every batch of Ipamorelin undergoes rigorous independent analytical testing to verify identity, purity, and consistency. This third-party testing ensures that researchers receive a product that meets strict quality specifications before it is approved for release.

The testing process includes:

• Identity verification through mass spectrometry

• Purity analysis using high-performance liquid chromatography (HPLC)

• Batch-to-batch consistency checks

• Residual solvent analysis to confirm complete lyophilization

With a verified purity exceeding 99%, Ipamorelin meets the high standards required for serious laboratory research applications. Each vial contains only the lyophilized research compound with no unnecessary additives, fillers, or excipients.

Chemical and Physical Properties

Molecular Characteristics

Ipamorelin is a synthetic pentapeptide with a unique amino acid sequence that includes non-standard amino acids Aib (aminoisobutyric acid) and D-2-Nal (D-2-naphthylalanine).

Detailed Molecular Information:

• Molecular Formula: C₃₈H₄₉N₉O₅

• Molecular Mass: 711.85 daltons

• CAS Number: 170851-70-4

• Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH₂

• IUPAC Name: (2S)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[[2-(2-amino-2-methylpropanoyl)amino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]-3-phenylpropanoyl]amino]hexanamide

Structural Features:

• Linear pentapeptide (5 amino acids)

• Contains Aib (aminoisobutyric acid) — a non-standard, achiral amino acid

• Contains D-2-Nal (D-2-naphthylalanine) — a non-standard synthetic amino acid

• Contains D-Phe (D-phenylalanine) — the D-isomer of phenylalanine

• Contains histidine, which is important for GHSR binding

• Amidated C-terminus (NH₂)

Amino Acid Sequence Breakdown:

The presence of multiple non-standard amino acids (Aib, D-2-Nal, D-Phe) distinguishes Ipamorelin from naturally occurring peptides and contributes to its resistance to enzymatic degradation, making it more stable in laboratory settings.

Physical Form and Storage

The product is supplied as a lyophilized (freeze-dried) powder within a sterile, sealed vial. Lyophilization preserves the chemical integrity of the peptide by removing water content while maintaining the compound’s structure.

Recommended Storage Conditions:

• Store lyophilized powder at -20°C (-4°F) or below for long-term preservation

• Protect from light exposure

• Keep desiccated to prevent moisture absorption

• Allow vial to reach room temperature before opening to avoid condensation

• Avoid repeated freeze-thaw cycles once reconstituted

Stability Considerations:
Ipamorelin is generally stable when stored properly in lyophilized form. The presence of D-amino acids and non-standard residues enhances its resistance to proteolytic degradation compared to all-L-amino acid peptides.

Once reconstituted with an appropriate sterile solvent, the solution should be used promptly according to laboratory protocols. For extended storage after reconstitution, aliquoting and freezing below -20°C is recommended.

Intended Use and Regulatory Status

Research Use Only

Ipamorelin is classified as a research chemical and is intended exclusively for laboratory and in vitro experimentation. This designation means the product is sold strictly for:

• In vitro testing — experiments conducted in controlled laboratory environments

• Cell culture studies — investigating GHSR signaling in pituitary cell lines

• Receptor binding assays — studying growth hormone secretagogue receptor interactions

• Endocrinology research — investigating growth hormone axis regulation

• Analytical research — chemical analysis and characterization studies

• Scientific investigation — basic research into peptide structure and function

Important Regulatory Notice

This product is not a drug, food, cosmetic, or medical device. Bodily introduction of any kind into humans or animals is strictly forbidden by law. The product should only be handled by licensed, qualified professionals working in appropriate laboratory facilities.

The supplier is a chemical supplier, not a compounding pharmacy or outsourcing facility under Sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act. All product information provided is for educational purposes only and does not constitute medical advice or clinical recommendations.

Handling and Safety Guidelines

Professional Handling Required

Ipamorelin should only be handled by trained laboratory personnel wearing appropriate personal protective equipment (PPE), including:

• Laboratory coat

• Nitrile gloves

• Safety goggles or face shield

• Appropriate respiratory protection if aerosolization is possible

Reconstitution Protocol

For laboratory use, the lyophilized powder should be reconstituted with a sterile, compatible solvent. Standard practice includes:

1. Allow the sealed vial to reach room temperature — approximately 15-30 minutes

2. Clean the rubber stopper with an alcohol swab

3. Add the calculated volume of solvent to achieve desired concentration

4. Gently swirl or roll the vial between palms — do not shake vigorously to avoid foaming

5. Allow complete dissolution before use — this typically takes 2-5 minutes

Reconstitution Example for Ipamorelin 5MG:
For researchers needing a 5mg/mL working solution, add 1mL of sterile solvent to the 5mg vial. For a 2.5mg/mL solution, add 2mL of solvent. For a 1mg/mL solution, add 5mL of solvent. For a 0.5mg/mL solution, add 10mL of solvent. Always verify calculations before proceeding with experiments.

Solvent Considerations:
Ipamorelin is water-soluble. Researchers should determine the appropriate solvent based on their specific experimental protocol. Common options include sterile water for injection, bacteriostatic water, or buffered solutions such as phosphate-buffered saline (PBS). The choice of solvent may affect peptide stability and should be validated for each experimental application.

Disposal Considerations

Dispose of Ipamorelin and any contaminated materials in accordance with federal, state, and local regulations for chemical waste disposal. Do not dispose of in regular trash or down drains unless permitted by local guidelines.

Research Applications

Ipamorelin is used in various laboratory research contexts, primarily focused on endocrinology and growth hormone axis regulation. Typical applications include:

Growth Hormone Secretagogue Receptor (GHSR) Studies:
The primary research interest in Ipamorelin revolves around its selective activation of GHSR. Researchers use Ipamorelin to study:

• GHSR binding affinity and kinetics

• Receptor activation mechanisms and conformational changes

• GHSR signaling pathways and downstream effectors

• Receptor desensitization and internalization

Pituitary Cell Culture Studies:
Ipamorelin is used in controlled pituitary cell culture systems to investigate:

• Somatotroph (growth hormone-producing cell) function

• Growth hormone synthesis and secretion mechanisms

• Pituitary cell signaling pathways

• Feedback regulation of the growth hormone axis

Signal Transduction Research:
Researchers use Ipamorelin to study downstream signaling events following GHSR activation, including:

• Gq/11 protein activation

• Phospholipase C (PLC) stimulation

• Inositol trisphosphate (IP3) and diacylglycerol (DAG) production

• Protein kinase C (PKC) activation

• Intracellular calcium mobilization

Neuroendocrine Regulation Studies:
Ipamorelin is used to investigate:

• Hypothalamic-pituitary-somatotropic axis regulation

• Growth hormone-releasing hormone (GHRH) and somatostatin interactions

• Central nervous system control of growth hormone secretion

• Circadian rhythms in growth hormone release

Selectivity and Specificity Research:
The selective profile of Ipamorelin makes it valuable for:

• Comparing GHSR activation patterns across different secretagogues

• Isolating GH-specific effects from broader hormonal changes

• Studying the minimal structural requirements for GHSR selectivity

Receptor Binding and Structure-Activity Relationship (SAR) Analysis:
Ipamorelin’s unique structure (containing Aib, D-2-Nal, and D-Phe) makes it useful for:

• Identifying critical residues for GHSR binding and activation

• Understanding how peptide structure affects receptor selectivity

• Developing even more selective GHSR research tools

In Vitro Efficacy Studies:
Researchers use Ipamorelin to study:

• Concentration-response relationships for growth hormone release

• Time-course of GHSR-mediated signaling

• Interactions with other growth hormone axis modulators

Researchers should design their experimental protocols based on peer-reviewed literature and established laboratory practices specific to growth hormone secretagogues.

What Makes This Product Different

High Selectivity for GHSR

Unlike earlier growth hormone secretagogues such as GHRP-6 and GHRP-2, which were associated with increases in cortisol and prolactin, Ipamorelin demonstrates high selectivity for growth hormone release. This selectivity makes Ipamorelin a valuable research tool for investigators studying isolated growth hormone axis activation without confounding hormonal effects.

Unique Non-Standard Amino Acid Composition

Ipamorelin contains three non-standard amino acids:

• Aib (aminoisobutyric acid) — An achiral, non-standard amino acid that introduces structural rigidity

• D-2-Nal (D-2-naphthylalanine) — A synthetic amino acid with a naphthyl side chain

• D-Phe (D-phenylalanine) — The D-isomer of phenylalanine

This unique composition distinguishes Ipamorelin from naturally occurring peptides and contributes to its stability and receptor binding properties.

Enhanced Enzymatic Stability

The presence of D-amino acids and non-standard residues makes Ipamorelin more resistant to proteolytic degradation compared to all-L-amino acid peptides. This enhanced stability is valuable for laboratory research applications where peptide integrity over time is important.

Third-Generation Growth Hormone Secretagogue

Ipamorelin represents a third-generation growth hormone secretagogue, developed after earlier compounds like GHRP-6 and GHRP-2. Its development focused on improving selectivity and reducing off-target hormonal effects, making it a refined research tool for GHSR studies.

Rigorous Quality Control

Unlike research chemicals sold without verification, Ipamorelin comes with documented third-party testing for every batch. This commitment to quality assurance gives researchers confidence in the consistency and reliability of their experimental results.

Complete Documentation

Each product listing includes full chemical specifications, including molecular formula, molecular mass, CAS number, and amino acid sequence. This transparency allows researchers to verify the exact compound they are working with.

Appropriate Packaging for Research Use

The sterile, sealed vial packaging protects the lyophilized powder from environmental contaminants. The 5mg concentration is particularly useful for experiments requiring precise, smaller-scale handling.

Batch Traceability

Each package of Ipamorelin includes batch identification numbers that allow researchers to trace their material back to original manufacturing and testing records. This traceability is essential for reproducible research and quality documentation.

Frequently Asked Questions for Researchers

What is the purity level of Ipamorelin?

Each batch is tested to verify purity exceeding 99%. Individual certificates of analysis are available upon request.

How should the lyophilized powder be stored?

Store at -20°C or below, protected from light and moisture. Avoid repeated freeze-thaw cycles once reconstituted.

What solvent should be used for reconstitution?

Ipamorelin is water-soluble. Researchers should determine the appropriate solvent based on their specific experimental protocol. Common options include sterile water for injection, bacteriostatic water, or buffered solutions such as phosphate-buffered saline (PBS).

Is this product sterile?

The lyophilized powder is manufactured under aseptic conditions, but researchers should follow standard laboratory practices for handling research chemicals. For cell culture applications, additional filtration using a 0.22-micron filter may be appropriate.

What is the significance of the CAS number 170851-70-4?

The CAS number is a unique identifier for Ipamorelin, allowing researchers to verify they are working with the correct chemical compound when ordering or referencing the peptide in publications.

What is the amino acid sequence of Ipamorelin?

The sequence is Aib-His-D-2-Nal-D-Phe-Lys-NH₂, where Aib is aminoisobutyric acid and D-2-Nal is D-2-naphthylalanine.

How does Ipamorelin differ from GHRP-6 and GHRP-2?

Unlike GHRP-6 and GHRP-2, which have been associated with increases in cortisol and prolactin in addition to growth hormone, Ipamorelin demonstrates high selectivity for growth hormone release with minimal effects on other pituitary hormones.

What makes Ipamorelin more stable than all-L-amino acid peptides?

Ipamorelin contains D-amino acids (D-2-Nal and D-Phe) and the non-standard residue Aib. D-amino acids are not recognized by most proteases, and Aib introduces structural constraints, both of which enhance resistance to enzymatic degradation.

Can Ipamorelin be used in combination with other research peptides?

Researchers should determine compatibility based on their specific experimental design. Standard laboratory practice includes testing interactions in control experiments before full-scale implementation.

What is the significance of the 5mg vial size?

The 5mg vial size is optimized for research applications requiring precise, smaller-scale handling. For larger-scale experiments, multiple vials can be used to achieve the desired quantity.

Final Notes for Laboratory Researchers

Ipamorelin represents a high-purity research tool for qualified professionals conducting legitimate scientific investigations into growth hormone secretagogue receptor signaling, pituitary somatotroph function, neuroendocrine regulation, and related endocrinological fields. With documented third-party testing, complete chemical specifications, and appropriate packaging for laboratory use, this product meets the standards expected by serious researchers.

The unique composition of non-standard amino acids (Aib, D-2-Nal, D-Phe) distinguishes Ipamorelin from naturally occurring peptides and contributes to its stability and selective receptor binding properties. The 5mg vial size is optimized for smaller-scale experiments, preliminary studies, and protocols requiring precise handling.

For research use only. Not for human or animal consumption. Handle only in appropriate laboratory facilities with proper safety equipment and training.