MOTS-C 5MG Research Peptide — Mitochondrial-Derived Peptide for Laboratory Use

Product Overview

MOTS-C is a research-grade mitochondrial-derived peptide (MDP) encoded within the mitochondrial genome. It is supplied as a sterile lyophilized powder in sealed vials. Each package contains ten vials, with each vial holding 5mg of the research compound. This product is manufactured exclusively for scientific investigation and in vitro laboratory experimentation.

Key Specifications at a Glance:

• Quantity: 5mg per vial, 10 vials per pack

• Form: Lyophilized (freeze-dried) powder

• Purity: >99% verified by third-party testing

• Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂

• Molecular Mass: 2174.60

• CAS Number: 1627580-64-6

• Sequence: MRWQEMGYIFYPRKLR (H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH) 

• Research Use Only: Not for human or animal consumption

Understanding MOTS-C: The Research Context

MOTS-C is a synthetic research peptide that corresponds to a naturally occurring mitochondrial-derived peptide encoded within the mitochondrial genome. Unlike most peptides that are encoded by nuclear DNA, MOTS-C is one of a growing class of peptides encoded by short open reading frames (sORFs) within mitochondrial DNA (mtDNA) . MOTS-C 5mg for Sale

Key Research Interests:

• AMPK pathway activation and metabolic regulation 

• Glucose metabolism and insulin sensitivity

• Osteoclast differentiation and bone metabolism 

• Anti-inflammatory and antinociceptive mechanisms 

• Mitochondrial biology and intercellular communication

Researchers utilize MOTS-C in controlled laboratory settings to study the emerging field of mitochondrial-derived peptides and their roles in cellular metabolism. The peptide is of particular interest to investigators focused on metabolic disorders, osteoporosis, mitochondrial dysfunction, and the fundamental biology of intercellular signaling .

The Significance of Mitochondrial-Derived Peptides:
Mitochondria are organelles traditionally known for energy production, but research has revealed that they also produce signaling molecules, including a family of peptides encoded within mitochondrial DNA. MOTS-C is a 16-amino acid peptide that has been the subject of research into its potential roles in:

• Metabolic regulation through AMPK activation

• Cellular stress responses

• Bone metabolism and osteoclast formation 

• Systemic metabolic homeostasis

This emerging class of signaling molecules represents a relatively new area of biological investigation, and MOTS-C serves as a valuable research tool for exploring mitochondrial-nuclear communication pathways.

The MOTS-C Amino Acid Sequence

MOTS-C is a 16-amino acid peptide with the following sequence :

Full Sequence: H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH

Abbreviated Sequence: MRWQEMGYIFYPRKLR

Key Sequence Features:

• Contains multiple aromatic amino acids (tryptophan, tyrosine, phenylalanine)

• Includes positively charged residues (arginine, lysine)

• Contains two methionine residues

• Length of 16 amino acids

• Molecular weight: 2174.60 

The presence of multiple aromatic and positively charged residues contributes to the peptide’s structural properties and potential interaction with cellular targets.

MOTS-C 5MG vs. 10MG vs. 20MG vs. 40MG: Choosing the Right Quantity for Your Research

Researchers often ask which quantity best suits their laboratory protocols. MOTS-C is available in multiple vial sizes to accommodate different research scales:

Choosing the Right Vial Size:

• MOTS-C 5MG — Ideal for preliminary pilot studies, initial dose-finding experiments, small-scale screening assays, and research requiring precise handling of smaller quantities at a lower initial investment

• MOTS-C 10MG — Suitable for moderate-scale studies, standard cell culture experiments, and protocols requiring more material per vial

• MOTS-C 20MG & 40MG — Best for large-scale experiments, extended time-course studies, high-throughput screening, and maximum cost efficiency

All sizes share identical chemical properties, purity standards (>99%), and quality assurance protocols. The choice depends on the specific requirements of your research design and the scale of your experiments. MOTS-C 5mg for Sale

Third-Party Testing and Quality Assurance

Every batch of MOTS-C undergoes rigorous independent analytical testing to verify identity, purity, and consistency. This third-party testing ensures that researchers receive a product that meets strict quality specifications before it is approved for release . MOTS-C 5mg for Sale

The testing process includes:

• Identity verification through mass spectrometry

• Purity analysis using high-performance liquid chromatography (HPLC)

• Batch-to-batch consistency checks

• Residual solvent analysis to confirm complete lyophilization

With a verified purity exceeding 99%, MOTS-C meets the high standards required for serious laboratory research applications. Each vial contains only the lyophilized research compound with no unnecessary additives, fillers, or excipients. MOTS-C 5mg for Sale

Chemical and Physical Properties

Molecular Characteristics

MOTS-C is a synthetic 16-amino acid peptide with a relatively high molecular mass compared to smaller research peptides. MOTS-C 5mg for Sale

Detailed Molecular Information:

• Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂

• Molecular Mass: 2174.60 daltons 

• CAS Number: 1627580-64-6

• Sequence: MRWQEMGYIFYPRKLR

• Number of Amino Acids: 16

• Smiles Notation: Complex peptide structure as detailed in chemical databases 

Structural Features:

• Linear peptide (non-cyclic)

• Contains two methionine residues (susceptible to oxidation)

• Multiple aromatic residues (Trp, Tyr, Phe)

• Positively charged residues at positions 2, 13, 14, and 16

Physical Form and Storage

The product is supplied as a lyophilized (freeze-dried) powder within a sterile, sealed vial. Lyophilization preserves the chemical integrity of the peptide by removing water content while maintaining the compound’s structure. MOTS-C 5mg for Sale

Recommended Storage Conditions:

• Store lyophilized powder at -20°C (-4°F) or below for long-term preservation (stable for up to 3 years) 

• For extended storage, -80°C is recommended for stock solutions 

• Protect from light exposure

• Keep desiccated to prevent moisture absorption

• Allow vial to reach room temperature before opening to avoid condensation

• Avoid repeated freeze-thaw cycles once reconstituted 

Stability Considerations:
MOTS-C contains methionine residues, which can be susceptible to oxidation. For this reason, minimizing air exposure and avoiding repeated opening of stock vials is particularly important. Once reconstituted, solutions should be stored in separate aliquots to prevent repeated freeze-thaw cycles. When stored at -80°C, stock solutions can be used within 6 months; when stored at -20°C, use within 1 month. MOTS-C 5mg for Sale

Solubility Information:

• DMSO: ≥1 mg/mL 

• For in vivo applications, CMC-NA (carboxymethylcellulose sodium) can be used to prepare homogeneous suspensions at concentrations ≥5 mg/mL 

Biological Activity and Mechanism of Action

MOTS-c is known to exert its biological effects primarily through activation of the AMPK (AMP-activated protein kinase) pathway and inhibition of MAP kinases-c-fos signaling pathway .

Key Biological Activities Reported in Research Literature:

AMPK Activation Pathway:
MOTS-c induces the accumulation of AMP analog AICAR, increases activation of AMPK, and promotes expression of its downstream target GLUT4. This mechanism is central to its effects on glucose uptake and insulin sensitivity. MOTS-C 5mg for Sale

Intended Use and Regulatory Status

Research Use Only

MOTS-C is classified as a research chemical and is intended exclusively for laboratory and in vitro experimentation. This designation means the product is sold strictly for:

• In vitro testing — experiments conducted in controlled laboratory environments

• Cell culture studies — investigating AMPK pathway activation and metabolic signaling

• Metabolic research — studying glucose metabolism, insulin sensitivity, and energy homeostasis 

• Bone metabolism research — investigating osteoclast differentiation and osteoporosis models 

• Mitochondrial biology — exploring mitochondrial-nuclear communication pathways

• Analytical research — chemical analysis and characterization studies

• Scientific investigation — basic research into mitochondrial-derived peptides

Important Regulatory Notice

This product is not a drug, food, cosmetic, or medical device. Bodily introduction of any kind into humans or animals is strictly forbidden by law. The product should only be handled by licensed, qualified professionals working in appropriate laboratory facilities.

Products are for research use only. Not for human use. Suppliers do not sell to patients .

The supplier is a chemical supplier, not a compounding pharmacy or outsourcing facility under Sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act. All product information provided is for educational and research purposes only and does not constitute medical advice or clinical recommendations. MOTS-C 5mg for Sale

Handling and Safety Guidelines

Professional Handling Required

MOTS-C should only be handled by trained laboratory personnel wearing appropriate personal protective equipment (PPE), including:

• Laboratory coat

• Nitrile gloves

• Safety goggles or face shield

• Appropriate respiratory protection if aerosolization is possible

Reconstitution Protocol

For laboratory use, the lyophilized powder should be reconstituted with a sterile, compatible solvent. Standard practice includes :

1. Allow the sealed vial to reach room temperature — approximately 15-30 minutes

2. Clean the rubber stopper with an alcohol swab

3. Add the calculated volume of solvent to achieve desired concentration

4. Gently swirl or roll the vial between palms — do not shake vigorously to avoid foaming

5. Allow complete dissolution before use — this typically takes 2-5 minutes

6. For increased solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath 

Reconstitution Example for MOTS-C 5MG:
For researchers needing a 5mg/mL working solution, add 1mL of sterile solvent to the 5mg vial. For a 2.5mg/mL solution, add 2mL of solvent. For a 1mg/mL solution, add 5mL of solvent. Always verify calculations before proceeding with experiments. MOTS-C 5mg for Sale

Solvent Considerations:

• DMSO: Soluble at ≥1 mg/mL for stock solutions 

• In vivo suspensions: CMC-NA (carboxymethylcellulose sodium) can be used to prepare homogeneous suspensions at concentrations ≥5 mg/mL 

• For aqueous solutions, test solubility in your specific buffer system

Stock Solution Storage:
Once prepared, store stock solutions in separate aliquots to avoid repeated freezing and thawing. When stored at -80°C, use within 6 months; when stored at -20°C, use within 1 month .

Disposal Considerations

Dispose of MOTS-C and any contaminated materials in accordance with federal, state, and local regulations for chemical waste disposal. Do not dispose of in regular trash or down drains unless permitted by local guidelines. MOTS-C 5mg for Sale

Research Applications

MOTS-C is used in various laboratory research contexts, primarily focused on metabolic regulation, bone biology, and AMPK signaling. Typical applications include:

AMPK Pathway and Metabolic Research:
The primary research interest in MOTS-C revolves around its activation of the AMPK pathway. Researchers use MOTS-C to study :

• AMPK activation mechanisms and downstream signaling

• Glucose uptake and insulin sensitivity in cell culture models

• Glycolysis regulation and metabolic flux

• Prevention of high-fat diet-induced metabolic changes

Osteoporosis and Bone Metabolism Research:
MOTS-C has been extensively studied in bone research models. Research demonstrates :

• Inhibition of RANKL-induced osteoclast differentiation

• Prevention of ovariectomy (OVX)-induced bone loss

• AMPK-dependent inhibition of osteoclastogenesis

• Osteogenic differentiation of bone marrow mesenchymal stem cells

Research applications in bone science include:

• Osteoclast formation and activity studies

• Bone mineral density investigations

• Postmenopausal osteoporosis models

• RANKL signaling pathway research

Anti-Inflammatory and Antinociceptive Research:
MOTS-C exerts anti-inflammatory effects through AMPK pathway activation. Research applications include :

• Inflammatory cytokine modulation

• MAP kinase-c-fos signaling inhibition

• Pain pathway investigations

Cell Culture Investigations:
Researchers use MOTS-C in controlled cell culture systems to study:

• AMPK activation and downstream gene expression

• Osteoclast differentiation from precursor cells

• Osteogenic differentiation of mesenchymal stem cells 

• Glucose metabolism in various cell lines

In Vivo Research Models:
Preclinical research has utilized MOTS-C in animal models with observations including :

• Improved glucose clearance at 0.5 mg/kg/day

• Prevention of high-fat diet-induced obesity at 5 mg/kg

• Reduced bone loss in ovariectomy models at 5 mg/kg/day for 12 weeks

• Attenuation of aortic calcification at 5 mg/kg

Small-Scale and Pilot Applications:
The 5MG vial size is specifically suited for:

• Preliminary dose-finding studies

• Small-scale screening assays

• Initial pathway validation experiments

• Cost-effective entry into MOTS-C research

Researchers should design their experimental protocols based on peer-reviewed literature and established laboratory practices specific to mitochondrial-derived peptides. MOTS-C 5mg for Sale

What Makes This Product Different

Mitochondrial Genome Origin

Unlike the vast majority of research peptides that are encoded by nuclear DNA, MOTS-C is encoded within the mitochondrial genome. This unique origin makes MOTS-C a valuable research tool for investigators studying mitochondrial biology and the emerging field of mitochondrial-derived signaling molecules. MOTS-C 5mg for Sale

AMPK Pathway Activation

MOTS-C is a well-characterized activator of the AMPK pathway, a central regulator of cellular energy homeostasis. This specific mechanism of action distinguishes MOTS-C from peptides that target other signaling pathways. MOTS-C 5mg for Sale

Broad Research Applications

MOTS-C has been validated across multiple research domains, including:

• Metabolic research (glucose homeostasis, insulin sensitivity)

• Bone biology (osteoporosis, osteoclast differentiation)

• Anti-inflammatory research (AMPK-mediated effects)

• Cardiovascular research (vascular calcification models)

Low-Dose 5MG Format for Pilot Studies

The 5mg vial size is ideal for:

• Preliminary pilot studies testing new hypotheses

• Initial dose-finding experiments before scaling up

• Cost-effective entry point for new research directions

• Precise handling for small-scale screening applications

Available in Multiple Vial Sizes for Research Scalability

MOTS-C is available in multiple vial sizes—5mg, 10mg, 20mg, and 40mg—allowing researchers to scale their experiments efficiently. Start with 5mg vials for pilot studies, then move to larger sizes as protocols are established and scaled up.

Rigorous Quality Control

Unlike research chemicals sold without verification, MOTS-C comes with documented third-party testing for every batch. This commitment to quality assurance gives researchers confidence in the consistency and reliability of their experimental results. MOTS-C 5mg for Sale

Complete Documentation

Each product listing includes full chemical specifications, including molecular formula, molecular mass, CAS number, and amino acid sequence. Certificates of analysis are available upon request .

Batch Traceability

Each package of MOTS-C includes batch identification numbers that allow researchers to trace their material back to original manufacturing and testing records. This traceability is essential for reproducible research and quality documentation. MOTS-C 5mg for Sale

Frequently Asked Questions for Researchers

What is the purity level of MOTS-C?

Each batch is tested to verify purity exceeding 99% via HPLC and mass spectrometry. Individual certificates of analysis are available upon request. MOTS-C 5mg for Sale

What are the available sizes for MOTS-C?

MOTS-C is available in multiple vial sizes: 5mg, 10mg, 20mg, and 40mg per vial. All sizes come in packages of 10 vials. MOTS-C 5mg for Sale

Which vial size should I choose for my research?

Choose 5MG for preliminary pilot studies, initial dose-finding experiments, small-scale screening assays, or when a lower initial investment is preferred. Larger sizes (10mg, 20mg, 40mg) offer better cost efficiency for established protocols and larger-scale studies.

What is the molecular weight of MOTS-C?

The molecular weight of MOTS-C is 2174.60 .

What is the CAS number for MOTS-C?

The CAS number is 1627580-64-6 .

What is the amino acid sequence of MOTS-C?

The sequence is MRWQEMGYIFYPRKLR (H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH).

How should the lyophilized powder be stored?

Store at -20°C or below, protected from light and moisture. Due to the presence of methionine residues, minimizing air exposure is particularly important. The powder is stable for up to 3 years at -20°C .

What solvent should be used for reconstitution?

MOTS-C is soluble in DMSO at ≥1 mg/mL for stock solutions. For in vivo applications, CMC-NA can be used to prepare homogeneous suspensions at ≥5 mg/mL. Researchers should test solubility in their specific buffer system .

How should stock solutions be stored?

Once prepared, store stock solutions in separate aliquots to avoid repeated freeze-thaw cycles. When stored at -80°C, use within 6 months; when stored at -20°C, use within 1 month .

Is this product sterile?

The lyophilized powder is manufactured under aseptic conditions, but researchers should follow standard laboratory practices for handling research chemicals. For cell culture applications, additional filtration using a 0.22-micron filter may be appropriate. MOTS-C 5mg for Sale

What is the mechanism of action of MOTS-C?

MOTS-C activates the AMPK pathway and inhibits MAP kinases-c-fos signaling pathway, leading to anti-inflammatory and metabolic effects.

What research applications is MOTS-C used for?

MOTS-C is studied in metabolic research (glucose homeostasis, insulin sensitivity), osteoporosis and bone metabolism (osteoclast differentiation, bone loss prevention), anti-inflammatory research, and AMPK signaling pathway investigations in laboratory cell culture and research models .

Can MOTS-C be used in combination with other research peptides?

Researchers should determine compatibility based on their specific experimental design. Standard laboratory practice includes testing interactions in control experiments before full-scale implementation. MOTS-C 5mg for Sale

Final Notes for Laboratory Researchers

MOTS-C 5MG represents a high-purity research tool for qualified professionals conducting legitimate scientific investigations into mitochondrial-derived peptides, AMPK signaling, metabolic regulation, bone metabolism, and related fields. With documented third-party testing, complete chemical specifications, and appropriate packaging for laboratory use, this product meets the standards expected by serious researchers. 

The 5MG vial size is specifically optimized for preliminary pilot studies, initial dose-finding experiments, small-scale screening assays, and research requiring precise handling of smaller quantities. For researchers who have established their protocols and require larger quantities, MOTS-C is also available in 10mg, 20mg, and 40mg vial sizes.

As a peptide encoded by mitochondrial DNA with well-characterized AMPK-activating properties, MOTS-C offers unique research opportunities in the growing fields of mitochondrial signaling, metabolic regulation, and bone biology .

For research use only. Not for human or animal consumption. Handle only in appropriate laboratory facilities with proper safety equipment and training.